Time Line of the Development of GlycoBiology and GlycoNutritionals

1880s - Characterization of monosaccharides by Emil Fischer.

1952 - Fresh, not aged, Aloe gel heals radiation burns on rabbits (Clarence C. Lushbaugh, Cancer 1953 vol. 6)

1970 - 500 glycobiology papers published.

1976 - Research paper identifies the 8 sugars found in biological glycoproteins and glycolipids.

1980 - 1500 glycobiology papers published.

1990 - 4000 glycobiology papers published.

1990 - Journal of Glycobiology started by Oxford University.

1990 - "Capitalizing on Carbohydrates" by John Hodgson in BioTechnology, Vol 8 Feb. 1990 discussing cell surfaces containing carbohydrates involved in intercellular communication and essential for immune function.

1992 - Active component in Aloe gel is stabilized.

1995 - Nature: cell surface sugars necessary for recognition and immune function.

1996 - Harper's Biochemistry, Murray et al.: chapter on glycoproteins focuses on the 8 necessary sugars used in glycoproteins and glycolipids for cellular communication.

1998 - Integrative Physiological and Behavioral Science, January, vol. 33, #1, Articles on ADHD & Fibromyalgia

1998 - Acta Anatomica: special March issue on glycoscience; emphasizes that information content of biological sugar combinations exceeds that of the DNA code.

1998 - Healthy humans given radiologically labeled galactose, mannose and glucose incorporate all three directly into glycoproteins, proving that the body uses the different sugars as nutrients directly from the diet, instead of manufacturing them all from glucose alone. Biochimie ? 2002 recent advances.

2000 ? Now over 8000 glycobiology papers published.

2000 - GlycoScience.org website; March.

2000 - Newton Graphic Science Magazine: the science of cellular messaging.

2001 - Science: March 23 issue features "Carbohydrates and Glycobiology"; reviews structural and functional uses of 8 critical sugars in cellular physiology.

2001 - Physicians Desk Reference (PDR ) for Non-Prescription Drugs and Dietary Supplements lists for the first time glyconutrient complex, precursors for hormone health, and freeze-dried fruits and vegetables,

2001 - Impact of Glycobiology on Medicine (PDF) TRENDS in Immunology Vol 22 No 5 May 2001 Dr John Axford MD - Past President of the Royal Society of Medicine, London England says... "It is now becoming increasingly clear how important it is to understand these changes, to gain insight into their involvement in disease mechanisms and the potential for therapeutic interventions."

2001 - NIH grants consortium $34 million to study cell-cell communication interactions.

2002 - Australian Journal of Chemistry 55(2): Carbohydrates Special Issue

2002 - The Scientist 16:9 April 29 "Glycobiology Goes to the Ball."

2002 - France, Germany, Ireland, Italy, Liechtenstein, Spain, Switzerland, and the United Kingdom issue patents for a glyconutritional formula to Mannatech.

2002 - Scientific American: July, "Sweet Medicine: Building Better Drugs from Sugars"

2002 - New Scientist Archive: October story quotes JHU biochemist emphasizing glycobiology as the future of immunology, neurology, developmental biology, and disease research.

2002 - CAM: Volume 2, Issue 5 - December 2002 "Arthritis - Using the New Glyconutritionals."

2003 - M.I.T. Technology Review: February: "Glycomics" identified as "One of 10 Emerging Technologies That Will Change the World."

2003 - Yahoo lists 63,000 entries for the glyconutrient "mannose"

2003 - Book - Science or Miracle? by George DuBouch, Ph.D

2003 - Book "Miracle Sugars" by Elkins, Rita 50 page Mini-Book introducing anyone to the technology of Glyconutrition.

2004 - CD - Sweet Life by Momentum Media

2004 ? June 8, Psychology Today Magazine "How Sweet It Is" Summary: Some sugars are good for your health

2004 - Book - How To Survive on a Toxic Planet by Dr. Steve Nugent

2004 - DVD - Importance of Glyconutrients by H. Reginald McDaniel, M.D.

2004 - DVD - Glyconutrients and Stem Cell Production by H. Reginald McDaniel, M.D.

2004 ? November Accredited & Certification by University of Miami School of Medicine, Division of Complementary Medicine

For more info please see: http://glyconutritionals.myglycostore.c om/go/research Zach Thompson works Internationally as a Glyconutritional Consultant. He lives in the Blue Ridge Mountains of Virginia. He consults primarily in the USA, UK, Canada, Australia, & New Zealand.

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