Glutathione - Your Brains Master Antioxidant Defense

Free radicals and oxyradicals play an important role in the development and progression of many brain disorders such as brain injury, neurodegenerative disease, schizophrenia and Down syndrome.

Glutathione is the brain's master antioxidant and plays an important protective role in the brain.

According to Dr. Jimmy Gutman, "The brain is particularly susceptible to free radical attack because it generates more oxidative by-products per gram of tissue than any other organ."

Many neurological and psychiatric disease processes are characterized by... abnormalities in glutathione metabolism and antioxidant defenses."

Generation of reactive oxygen species (free radicals) and oxidative damage are an important cause of neuron (brain cell) death from brain injury.

Chemicals that cause toxicity to certain brain cells are known to decrease cerebral glutathione (GSH), making the cells more vulnerable to reactive oxygen species (ROS). (1)

On the other hand, over-expression of the glutathione peroxidase (GPX) enzyme potently decreases cell death from brain injury. (2)

Brain Injury and Glutathione - The Gender Difference

Researchers at Children's Hospital of Pittsburgh have found that males and females respond differently to brain injury. (3)

In animal models, levels of glutathione remain constant in females who have suffered a brain injury, but drop by as much as 80 percent in males with the same injury.

When glutathione levels drop, brain cells die much more quickly. This suggests that boys with brain injuries may require different life-saving treatments than girls.

N-acetyl-cysteine (NAC), a precursor of glutathione, already approved for use by the U.S. Food and Drug Administration to treat people who have overdosed on acetaminophen, may be an effective treatment for brain injury in boys whose brains are deprived of oxygen.

Brain Disorders and Glutathione - A Genetic Cause?

Genetics researchers have found that the glutathione S-transferase gene controls the onset of Alzheimer's, Parkinson's disease and determines, not if we get these diseases, but when. (4)

The glutathione S-transferase gene has previously been linked to the risk for Parkinson's disease among people who used pesticides.

A previous article covered the importance of glutathione in Parkinson's Disease.

Alzheimer's Disease and Glutathione

Free radicals and oxidative damage in neurons is known to be a primary cause of degenerative diseases like Alzheimer's disease.

Amyloid-ß peptide (Aß) accumulation in senile plaques, a pathological hallmark of Alzheimer's disease (AD), has been implicated in neuronal degeneration.

Amyloid plaques encroaching on the brain increase the production of free radicals, or oxidative stress. Antioxidants, such as vitamin C and E "mop up" the damaging free radicals.

Glutathione (GSH) precursors can prevent death of brain cells induced by amyloid plaques in Alzhiemer's disease, while substances that deplete GSH increase cell death. (5)

Evidence has been piling up over the link between the amount of an amino acid called homocysteine in the blood and the chance of developing Alzheimer's.

For people not genetically predisposed to developing Alzheimer's, cholesterol and homocysteine, largely caused by an unhealthy lifestyle, are the core causal factors.

Welsh GP, Andrew McCaddon, showed that the more homocysteine that patients with Alzheimer's had, the worse their mental performance, and the worse their "cognitive impairment," the less they had of the antioxidant glutathione. (6)

Glutathione and Mood Disorders

Studies have found that the mood stabilizing drug, valproate, used to treat epilepsy and bi-polar disorder, regulates expression of the genes that make glutathione-S-transferase (GST).

In addition, chronic treatment with lithium, another commonly prescribed mood stabilizer used in treating manic-depression, also increased levels of GST.

These findings led researchers to conclude that glutathione S-transferase may be a novel target for mood stabilizing drugs. (7)

Alcohol Consumption and Glutathione

Alcohol abuse is known to impair memory and other brain functions and increase brain cell death. A new study in rats has shown that alchol consumption causes fewer new brain cells to form and results in greater cell death. (8)

But rats that were fed alcohol along with Ebselen - a glutathione peroxidase mimic that acts as a free radical scavenger - showed no similar reduction in brain-cell formation and no increase in cell death.

Substances that Boost Glutathione Levels and Protect Brain Cells

Taking glutathione itself as a supplement does not boost cellular glutathione levels, since it breaks down in the digestive tract before it reaches the cells.

However, intravenous glutathione therapy and glutathione precursors or dietary supplements are effective in boosting intracellular levels of glutathione.

Intravenous Glutathione Injections: Intravenous glutathione injections have been shown to produce amazing and rapid results, in patients with Parkinson's disease. Following even a single dosage of intravenous glutathione, many of the symptoms of Parkinson's disease rapidly improve, often in as little as 15 minutes.

Glutathione Precursors: In the Alzheimer's study conducted by Welsh GP, Andrew McCaddon, adding the glutathione precursor, N-acetyl-cysteine (NAC) to a protocol that lowered homocysteine levels by simple supplementation with B12 and folate, resulted in prompt, striking, and sustained clinical improvement in nearly all the patients. (9)

Cucurmin (turmeric):Studies have shown that the Indian curry spice, cucurmin, has neuroprotective effects because of its ability to induce the enzyme, hemeoxygenase-1 (HO-1), which protects neurons exposed to oxidant stress. Treatment of brain cells called astrocytes, with curcumin, increases expression of HO-1 protein as well as glutathione S-transferase. (10)

Ebselen: Ebselen is a glutathione peroxidase mimic and potent synthetic antioxidant that acts as a neuroprotective agent and an inhibitor of free-radical induced apoptosis (cell death). It can protect brain cells from the neuro-toxic effects of alcohol consumption. (8)

Undenatured Whey Protein: Undenatured whey protein provides glutathione precursors, has been shown to raise intracellular glutathione levels in clinical trials, and has anecdotally been reported to improve the symptoms of Parkinson's disease.

References: 1. Journal of Neurochemistry, Vol. 88, No. 3, 2004 513-531
2. Journal of Neurochemistry, Vol. 87, No. 6, 2003 1527-1534
3. Researchers Find Brain Cells Die Differently in Males and Females; Pediatric Academic Societies Press release; 21-Apr-2004
4. Human Molecular Genetics, 2003, Vol. 12, No. 24 3259-3267
5. The Journal of Cell Biology, Volume 164, Number 1, 123-131; 5 January 2004
6. Biol Psychiatry. 2003 Feb;53(3):254-60
7. Journal of Neurochemistry, Vol. 88, No. 6, 2004 1477-1484
8. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7919-24. Epub 2003 Jun 05.
9. Am J Geriatr Psychiatry. 2003 Mar-Apr;11(2):246-9
10. Can Curry Protect Against Alzheimer's?; American Physiological Society (APS) Press Release; 16-Apr-2004

Copyright © 2004 Priya Shah

_____________________________________________
This article was first published in the May 2004 issue of The Glutathione Report, a newsletter featuring regular updates on the health benefits of glutathione. Get a Free report on Glutathione in Health and Disease
____________________________________________

---

Fatigue After WLS: Iron Deficiency May Be the Cause

I've been feeling a tired and slow lately. Just don't... Read More

Will Your Vitamins Be Banned?

Imagine this scenario by the end of next August...You contact... Read More

What are Phytochemicals (Phytonutrients)?

Don't be overwhelmed by this big word, ... Read More

The Eight Week Cholesterol Challenge

When I first started down this path I was looking... Read More

The Benefits of Whey Protein

The benefits of whey protein are so numerous and apply... Read More

Are You Flushing Your Money Down The Toilet...Literally?

Many of you are probably aware that The American Medical... Read More

The Importance of Taking a Multivitamin Supplement

It's absolutely crucial that your body gets the nutrients it... Read More

Calcium Reduces Osteoporosis Risk For Women On The Pill

The findings, published in the Journal of Clinical Endocrinology and... Read More

The Best Liquid Calcium with Boron

Best liquid calcium with boronNo longer is the search for... Read More

Vitamins: How To Keep Your Body Healthy By Using Vitamins Safely

Vitamins are an important part of a health diet. Unlike... Read More

Nutritional Supplements - How To Choose A High Quality Product

Looking for quality nutritional supplements can seem quite overwhelming at... Read More

Shopping for Supplements -- Living Healthy and Saving Money

When it comes to personalized weight loss programs and their... Read More

Amino Acids For Height Growth ? Boosting Your Growth Hormones

Many people take amino acids for height growth these days.... Read More

The Frightening But True Facts About Smoking

If you think that smoking is a harmless little hobby... Read More

GlutImmune: Powder for Immunity and Digestion

GlutImmune? is a very convenient high absorption source of glutamine.... Read More

What Good Is It To Stop Smoking If I Have Smoked For Years?

I often hear people say that they have smoked for... Read More

Introduing Supplements to Your Body & Improving Your Diet - A Guide of What to Expect

Part 1:A "better nutritional program" means the introduction of foods... Read More

The Colloidal Silver Controversy

Colloidal Silver might just be a wonderful thing and here's... Read More

Using Natural Remedies For Constipation

There are two basic types of constipation - organic and... Read More

How Selling Vitamins can Bring you Financial Freedom

Most people are becoming more health conscious. Many of the... Read More

Vitamins - Childrens and Multivitamins

Most parents' think their children are eating a fairly healthy... Read More

What Are Nutraceuticals and Why Are the Drug Companies Upset?

If you break the word apart, Nutra has to do... Read More

Increase Your Production Of Nitric Oxide

What Is Nitric Oxide (NO)?Nitric oxide (NO) is produced by... Read More

Creatine: More than a Sports Nutrition Supplement

Although creatine offers an array of benefits, most people think... Read More

Using Amino Acid Supplements

Amino acid supplements and amino acid food intake can bring... Read More

Vitamin Treatment Guide

Vitamins and minerals play a major role in becoming healthy... Read More

Vitamin Supplements in a Liquid World

Every day, it seems like we are living in an... Read More

The Secrets of Looking and Feeling Younger and HGH Supplements

The mankind has never stopped searching for the scerets of... Read More

What is a Supplement?

Supplement ? what is it?Supplement is a term that means... Read More

The Benefits of Protein Powders

I know protein is good for me, but do I... Read More

Discount Supplement

Discount Supplement ? what is it?Discount supplement is a term... Read More

Iron Supplement

Iron supplement - why iron?Why people need to use iron... Read More

Megadosing

If you're constantly digging your hand into a jar of... Read More